WebJun 17, 2024 · BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. BACE-1 deficiency elevated levels of transcription factors including Jun, Jund, Btg2, Erg1, Junb, Fos, and Fosb in ... WebMay 28, 2024 · Macrophage-derived exosomes (Mφ-Exos) are involved in tumor progression, but its role in glioma is not fully understood. RBP-J is related to …
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WebApr 1, 2004 · Immunohistochemical stainings for protectin (CD59) and for the macrophage/monocyte antigen were performed in muscle specimens of polymyositis (PM) and dermatomyositis (DM) patients. In control muscles, a granular immunostaining of CD59 at the surface of 10–15% from among muscle fibers and an intense reaction in … WebAug 15, 2024 · The transcriptional programs of tissue-resident macrophages are thought to be induced upon colonization of tissues by cues from local microenvironments (Okabe & … is it bonfire night
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WebAug 14, 2024 · Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the cellular adaptive-response network. Multiple extracellular signals, such as endoplasmic reticulum (ER) stress, cytokines, chemokines, and LPS, are connected to … WebMar 21, 2024 · BLVRB (Biliverdin Reductase B) is a Protein Coding gene. Diseases associated with BLVRB include Pyloric Stenosis and Achalasia.Among its related pathways are Cellular responses to stimuli and Nuclear receptors meta-pathway.Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-OH … WebThe downregulation of Btg2 after siRNA transfection also yielded a larger number of microglia expressing Ki67 ( Figures 7D-7F). Overall, these results show that microglial proliferation is ... is it bosses day or boss\\u0027s day