WebChloramphenicol diffuses into breast milk and readily crosses the placenta; fetal blood levels are 30–80% of maternal serum concentrations. Inactivation occurs primarily by … WebAdverse effects of chloramphenicol include. Bone marrow depression (most serious) Nausea, vomiting, and diarrhea. Gray baby syndrome (in neonates) There are 2 types of bone marrow depression: Reversible dose-related interference with iron metabolism: This effect is most likely with high doses or prolonged treatment or in patients with a severe ...
Chloramphenicol - Drugs and Lactation Database
WebChloramphenicol Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.; CAS Number: 56-75-7; Synonyms: Chloramphenicol; find Sigma-Aldrich-220551 MSDS, related peer-reviewed papers, technical documents, similar products & … WebSpecial precautions & notes: Chloramphenicol is degraded by light; please ensure the samples are protected from direct sunlight. Sample required: Approx. 1-2mLl of … scotts valley hardware store
Chapter 14 Multiple Choice Flashcards Quizlet
WebAdverse effects of chloramphenicol include. Bone marrow depression (most serious) Nausea, vomiting, and diarrhea. Gray baby syndrome (in neonates) There are 2 types of … WebJul 4, 2024 · Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa. It has also … Chloramphenicol succinate ester (an intravenous prodrug form) is readily excreted unchanged by the kidneys, more so than chloramphenicol base, and this is the major reason why levels of chloramphenicol in the blood are much lower when given intravenously than orally. See more Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. This effect is rare but sometimes fatal. The risk of AA is high enough that alternatives should be strongly considered. Treatments are … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various generic names in eastern Europe and Russia, including chlornitromycin, levomycetin, and chloromycetin; the … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent volume of distribution and penetrates effectively into all tissues of the body, including the brain. Distribution is not uniform, with … See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including See more scotts valley high school mateo