WebJun 1, 2024 · This topic review will cover the clinical use of high-dose MTX for treatment of malignancy, focusing on the prevention and management of toxicity. Intrathecal use of MTX and clinical use of low-dose and intermediate-dose MTX for both malignant and nonmalignant (eg, rheumatologic) conditions are covered elsewhere. (See appropriate … WebCytarabine (1b-arabinofuranosylcytosine, cytosine arabinoside or ara-C) ... In another dog with grade III hepatotoxicity, ultrasonography and liver aspirates revealed neither vacuolar hepatopathy nor lymphoma, so this was attributed to cytarabine toxicity. Grade I and II elevations were seen in two further dogs but no further investigations ...
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WebDec 2, 2016 · Cytarabine (Ara C) is considered the most effective chemotherapeutic agent in acute myeloid leukemia (AML) treatment. Several studies suggest that single nucleotide polymorphisms (SNPs) within the genes involving metabolic pathway of Ara C could influence in treatment outcomes, although their clinical relevance remains undetermined. … WebThe most common adverse effects of cytarabine include myelosuppression, nausea,vomiting, diarrhea, and immune-suppression related infection.5,9There is … clerks ajax.ca
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WebDec 22, 2011 · Cytarabine (ara-C) have revealed a cumulative dose-dependent hepatotoxicity. Several case reports have demonstrated direct histologic evidence of a hepatotoxic role for ara-C, expressed as increased ALT levels or as intrahepatic cholestasis. WebJun 1, 2024 · The most common adverse effects of cytarabine include myelosuppression, nausea, vomiting, diarrhea, and immune-suppression related infection. 5, 9 There is minimal published literature to establish a definitive link between cytarabine and hepatotoxicity. This is further complicated by the varying dosages of HiDAC. WebDec 20, 2024 · Direct chemotherapy-induced hepatotoxicity. Potentiation of preexisting liver disease, especially viral hepatitis. Altered hepatic drug metabolism due to underlying liver disease can result in higher or more persistent drug levels, thereby causing … clerks admin award