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Mechanical Unloading Activates FoxO3 to Trigger …

WebMay 5, 2024 · Similarly, the deacetylase SIRT1 has been shown to repress the ability of acetylated FOXO3 to induce BNIP3 expression to promote apoptosis and attenuate autophagy . On the evidence of these findings, the role of FOXO proteins in autophagy is likely to be context-dependent and can be a double-edged sword in terms of tumour … WebFOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. BNIP3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is … oschin telescope

Role of FoxO transcription factors in aging and age-related …

WebDec 5, 2007 · Thus, FoxO3 controls the two major systems of protein breakdown in skeletal muscle, the ubiquitin-proteasomal and autophagic/lysosomal pathways, independently. … WebThus, p8 RNAi increases FoxO3 association with bnip3 promoter, a known proautophagic FoxO3 target, resulting in higher bnip3 RNA and protein levels. Accordingly, bnip3 knockdown restores cell ... WebApr 8, 2013 · Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy In aggregate, these data point to FoxO3, a protein activated by … oschiri sassari