2024 How old is cisplatin

How old is cisplatin

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Nettet18. sep. 2024 · National Center for Biotechnology Information Nettet13. jun. 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors.

CISplatin Injection - Food and Drug Administration

Nettet29. jun. 2011 · Cisplatin is the most common agent used in combination with RT, and is one of the best studied. The standard regimen is three-weekly high-dose (100 mg/m 2) cisplatin (three cycles) concurrent with RT (2, 3). However, cisplatin at a dose of 100 mg/m 2 with concomitant RT is associated with significant acute and late toxicities (2, 4, … Nettet21. des. 2024 · Mechanistically, we noted that cisplatin treatment led to the up-regulation of NOX4, a key enzyme relevant to ferroptosis, which was normalized by the administration of myo-inositol. ... Eight-to-ten-weeks-old C57BL/6J mice weighing 20–24 mg were purchased from Guangdong Medical Laboratory Animal Center. hot for teacher cover band

Cisplatin Accord «Accord» - Felleskatalogen

NettetTry 0.45% NaCl which is the best solvent of cisplatin as far as I know (1 mg/ml). Also you can try 0.9% NaCl which id clinically approved and the solutions will be stable for more than 2 weeks at ... Nettet1. sep. 2024 · Cisplatin for injection has been administered at 50 mg/m 2 to 70 mg/m 2 intravenously per cycle once every 3 to 4 weeks. For heavily pretreated patients, an … NettetIt seems that cisplatin is stable in 0.9%NaCl solution, however, I get the information that there is an initial loss of 3% in less than 1 hour for a solution of cisplatin in 0.9%NaCl ... hot for teacher drum music

Cisplatin - an overview ScienceDirect Topics

Optimal cisplatin cycles in locally advanced cervical ... - Springer

NettetCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 system on the basolateral membrane of proximal tubular cells. • Cellular apoptosis/necrosis develops due to endoplasmic reticulum-induced stress, mitochondrial injury pathways, … NettetEpithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related death. The high mortality and morbidity associated with EOC are mostly due to late diagnosis and chemotherapy drug resistance. Currently, the standard first-line chemotherapy regimen is systemic administration of platinum-based chemotherapy combined with a taxane. A … hot for teacher drum sheet music pdfNettet15. jan. 2015 · Water is not a good solvent for cisplatin. 0.9% NaCl is well recommended. Cisplatin is highly soluble in DMF, so prepare a stock solution in DMF and dilute it with 0.9% saline or PBS. Cisplatin is ... linda westphal lwf

"Nettet5. okt. 2014 · Cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the trans-isomer (IARC 1981, Akron 2009). Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° C (HSDB 2009). " - How old is cisplatin

How old is cisplatin

Nettet7. feb. 2024 · Cisplatin is an old, platinum based anticancer drug that kills cancer cells by damaging their DNA. Its cytotoxic (cell-killing) properties were discovered by accident in the 1960s, when Barnett Rosenberg was performing experiments to analyse the effect of electric field on bacterial growth. Nettet11. apr. 2024 · Cisplatin (CISPt) III: Mesoporous silica (MSs)/Nanomotor: Zhou et al. L-DOPA: I: Systemic: This [email protected] provided good transdermic delivery for Parkinson treatments, since the azo-based nanomotor particles can start “in situ” the release when NIR irradiated.

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Nettet15. sep. 2024 · Case 1. 47 year old man with acute liver toxicity following cisplatin therapy.(1) A 47 year old man with bladder carcinoma developed jaundice 4 weeks after a single infusion of cisplatin given as adjuvant chemotherapy. The patient had no history of liver disease, alcohol abuse, risk factors for viral hepatitis or previous drug allergies. NettetThe discovery of cisplatin (cis-diamminedichloroplatinum, or cis-DDP) in the early 1960s generated a tremendous amount of research activity as scientists strove to understand how the drug worked in the human body to destroy cancer cells.

Nettet15. sep. 2024 · In some embodiments, the activating AR mutation is selected from one or more of one or more of AR gene amplification, one or more activating mutations in the ligand binding domain of AR (optionally selected from H874Y, T877A, T877S, T878A, and F876L), an AR splice variant lacking the ligand binding domain of AR (optionally ARV7 … Nettet15. sep. 2024 · A 47 year old man with bladder carcinoma developed jaundice 4 weeks after a single infusion of cisplatin given as adjuvant chemotherapy. The patient had no …

NettetOtotoxic effects may be more severe and detrimental in pediatric patients receiving cisplatin for injection, particularly in patients less than 5 years of age; consider … NettetAn "accidental" discovery leads to cisplatin.Because platinum was thought to have no biological activity, Dr. Rosenberg and his colleagues put platinum electrodes into a solution containing the common …

Nettet7. apr. 2024 · To analyze the effect of cisplatin cycles on the clinical outcomes of patients with locally advanced cervical cancer (LACC) treated with concurrent chemoradiotherapy ... The mean age was 51.0 years old (range 26–88 years old); squamous cell carcinoma (SCC) was more common, and majority of patients were in stage IIB. Overall, 44 ...

Nettet15. sep. 2024 · Cisplatin (cisplatin injection) (cis-diamminedichloroplatinum) is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. It is a white powder with the molecular formula PtCl 2 H 6 N 2, and a molecular weight of 300.05. linda weston movieNettet10. mar. 2015 · The history of cisplatin starts not in 1965, but in 1844, when it was first created by Italian chemist Michele Peyrone. For a long time it was known as Peyrone’s … hot for teacher albumNettetWhile cisplatin is best known as an anticancer drug, the history of the molecule goes all the way back to 1845 when it was discovered by an Michele Peyrone - leading to the molecule being initially known as 'Peyrone's salt'. Its synthesis is a beautiful illustration of the chemical principle known as the trans effect. linda westover photosNettetPreparation of cis-platin is not a difficult work if you are supplied with the starting materials. In the attached article, you will find the method of preparation together with … linda westrich spencer tennesseeNettet14. des. 2024 · Cisplatin is a platinum-based drug, first discovered by a scientist named Michele Peyrone in 1845. At the time, cisplatin was called Peyrone’s salt or Peyrone’s chloride. However, its cancer-fighting properties weren’t fully recognized until 1969. linda wetherell cadillac miNettetcisplatin ove rdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle. DESCRIPTION . Cisplatin Injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Each 50 mL or 100 mL amber vial of infusion concentrate contains: 1 mg/mL hot for teacher album coverNettet2. jul. 2024 · Cisplatin kan kun administreres under tilsyn av leger som er kvalifisert innen onkologi, og under forhold som tilrettelegger for adekvat monitorering og overvåkning. … linda wetters obituary