WebAug 27, 2024 · Klotho regulates many pathways involved in aging processes, such as the regulation of phosphate homeostasis, insulin signaling and Wnt signaling ( 5, 22 ). Additionally, Klotho also affects intracellular signaling pathways including p53/p21, cAMP, protein kinase C (PKC) and TGF-β ( 23, 24 ). WebConclusion: βKlotho inhibits proliferation of prostate cancer cells by downregulating ELK4. Both βKlotho and ELK4 expressions correlate with the prognosis of PCa, which may serve …
Alpha Klotho and phosphate homeostasis - PMC - National Center …
WebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large … WebJul 22, 2024 · The α - and β Klotho proteins have known biologic roles, but the function of γ Klotho is still elusive ( 7, 8 ). In this manuscript, we only focus on α Klotho (Klotho). Klotho is mostly expressed in the kidney as a transmembrane protein. jフィルム imx
The Klotho gene family and the endocrine fibroblast growth f ...
WebThe effects of beta-Klotho and FGF-15 on the ileal apical sodium bile transporter (ASBT) are unknown. beta-Klotho siRNA treatment of the mouse colon cancer cell line, CT-26, and the human intrahepatic biliary epithelial cells (HIBEC) resulted in upregulation of endogenous ASBT expression that was associated with reduced expression of the ... WebApr 12, 2024 · Anti-Aging β-Klotho Gene-Activated Scaffold Promotes Rejuvenative Wound Healing Response in Human Adipose-Derived Stem Cells. Apr 12, 2024. 3. Discussion WebDec 13, 2016 · We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10 −12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and … jファイルとは