Web7 oct. 2024 · Thus, LYSET represents a core component of the lysosomal enzyme trafficking pathway, underlies the pathomechanism for hereditary lysosomal storage disorders, … WebTwo different projects in our laboratory try to address how defects in intracellular trafficking might lead to human diseases: Mutations in mucolipin-1 have been linked to mucolipidosis type IV (MLIV), a lysosomal storage disorder characterized by severe neurological and ophthalmologic abnormalities.
The Role of N-Glycosylation in Folding, Trafficking, and ... - PLOS
Web18 mai 2016 · Protein trafficking in lysosomes 1 of 16 Protein trafficking in lysosomes May. 18, 2016 • 19 likes • 7,416 views Download Now Download to read offline … Web12 apr. 2024 · Endosomal trafficking is intricately linked to G protein-coupled receptors (GPCR) fate and signaling. Extracellular uridine diphosphate (UDP) acts as a signaling molecule by selectively activating the GPCR P2Y 6.Despite the recent interest for this receptor in pathologies, such as gastrointestinal and neurological diseases, there is … hattieosbourn
Intracellular trafficking of lysosomal membrane proteins
WebProsaposin is a precursor of lysosomal hydrolases activator proteins, saposins, and also acts as a secretory protein that is not processed into saposins. ... Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. J Cell Biol 210: 991–1002. doi: 10.1083/jcb.201502029 [PMC free article] [Google Scholar] Articles from ... Web22 dec. 2024 · Lysosomal alterations are common in cancer cells. The increased expression and altered trafficking of lysosomal enzymes participates in tissue invasion, … Web2 feb. 2016 · Here, we find that enhancement of a single therapeutic pathway centered on hydrolase trafficking and lysosomal function potently reduces α-synuclein … bootstrap wrapper plugin