2024 Npc intracellular cholesterol transporter 1

Npc intracellular cholesterol transporter 1

Author: uwtv

August undefined, 2024

WebThere are 2 general ways that cholesterol can move intracellularly, vesicular and nonvesicular. 3 Cholesterol is present in the membranes of intracellular vesicles that shuttle among compartments. Vesicular traffic typically requires an intact cytoskeleton, the tracks along which vesicles move, and ATP, providing energy for motor proteins. WebNPC1 ( англ. NPC intracellular cholesterol transporter 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 18-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 1 278 амінокислот, а молекулярна маса — 142 167 [5] . Послідовність амінокислот

NPC intracellular cholesterol transporter 1 (human) - PubChem

WebAlso known as. English. NPC1. protein-coding gene in the species Homo sapiens. NPC. NPC intracellular cholesterol transporter 1. SLC65A1. POGZ. Web7 okt. 2008 · NPC is characterized by the accumulation of cholesterol and glycosphingolipids in the LE. NPC1 is a multispanning protein that is localized to the limiting membrane of LEs. It contains three lumenally oriented domains including an N-terminal domain (NTD). Whether NPC1 functions as a transporter remains controversial. how to make a bird beak face mask

NPC1, intracellular cholesterol trafficking and atherosclerosis

WebNpc1 Name NPC intracellular cholesterol transporter 1 Synonyms A430089E03Rik, C85354, D18Ertd139e, D18Ertd723e, lcsd, nmf164 Feature Type protein coding gene IDs MGI:1097712 NCBI Gene: 18145 Alliance gene page Transcription Start Sites 7 TSS Location & Maps more Sequence Map Chr18:12322749-12369457 bp, - strand From … WebPharos : Target Details - NPC1 Targets Ligands About Tutorials lightbulb feedback Protein Classes help help No PANTHER Classes or DTO Classes found Expression Data (0 Tissues) help help tutorial lightbulb No expression data found Protein Sequence and Structure help help Residue Counts Protein Sequence Find Targets by Sequence search WebNPC intracellular cholesterol transporter 1 (human) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW … how to make a basic salad

Endolysosomal cholesterol export: More than just NPC1

NPC1 Gene - GeneCards NPC1 Protein NPC1 Antibody

Web5 mrt. 2024 · NPC intracellular cholesterol transporter 1. Gene ID: 4864, updated on 5-Mar-2024. Gene type: protein coding. Also known as: NPC; POGZ; SLC65A1. See all … WebNiemann-Pick type C patients and mice show intracellular cholesterol accumulation leading to hepatic failure with increased inflammatory response. The complement cascade, ... In conclusion, these results suggest that NPC cells cannot transport vitamin E correctly leading to α-TOH buildup in the endosomal/lysosomal system. how to make a boo bag for halloweenWebits cholesterol esters are cleaved by acid lipase to release free cholesterol for cellular use (1). NPC2 protein is a small (25-kDa) globular protein (2, 3) that is thought to bind the choles-terol released from LDL and transfer it onto NPC1 (4–9), a 1278-residue protein with 13 transmembrane domains (10) (Fig. 1A). how to make a calculated column sharepoint

"Web29 mrt. 2024 · NPC2 NPC intracellular cholesterol transporter 2 [ (human)] Gene ID: 10577, updated on 8-Dec-2024. Summary. This gene encodes a protein containing a … " - Npc intracellular cholesterol transporter 1

Npc intracellular cholesterol transporter 1

The Niemann-Pick type diseases - A synopsis of inborn errors in ...

Web15 feb. 2014 · Mutations in the NPC1 gene can be found in the majority of NPC patients, who accumulate massive amounts of cholesterol and other lipids in the LE/LY due to a … WebSymbol Description Category UniProt ID GIFtS GC id Score; 1: NPC1: NPC Intracellular Cholesterol Transporter 1: Protein Coding: O15118: 56: GC18M023506: 79.57: 2: NPC1L1

Did you know?

Web12 apr. 2024 · Abnormal NPC1 and NPC2 proteins are believed to function in a coordinate fashion in the post-lysosomal/late endosomal transport of cholesterol and other molecules, although their precise function is unknown [62, 63]. Clinical presentation of NPC disease is extremely heterogeneous with the age of onset ranging from the perinatal period to … Web1 nov. 2006 · Transfection of NP-C fibroblasts with wild-type NPC1 cDNA resulted in correction of their excessive lysosomal storage of LDL cholesterol, thereby defining the critical role of NPC1 in regulation of intracellular cholesterol trafficking. 1,399 PDF The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). M. Garcia-Calvo, J. Lisnock, …

WebNPC1 INFORMATION. Proteini. Full gene name according to HGNC. NPC intracellular cholesterol transporter 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. NPC1 (SLC65A1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).

Web10 aug. 2024 · Watari et al. (1999) concluded that transport of the NPC1 protein to the cholesterol-laden lysosomal compartment is essential for expression of its biologic … Web21 mrt. 2024 · NPC1 (NPC Intracellular Cholesterol Transporter 1) is a Protein Coding gene. Diseases associated with NPC1 include Niemann-Pick Disease, Type C1 and …

Web9 mrt. 2024 · NPC-1 gene is regulated by cAMP. It plays a role in normal cholesterol homeostasis and is essential for normal adrenal development and function. NPC1 …

Web7 jun. 2004 · NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol … how to make a bushel basket linerWebNiemann-Pick disease type C (NPC) is an autosomal recessive disorder caused by mutations of NPC1 or NPC2, which encode the proteins that are responsible for intracellular cholesterol trafficking. Loss of this function results in the accumulation of cholesterol-related products, such as oxysterols, sphingolipids, and NPC-related bile … how to make a cinnamon scented broomWebNCBI Full Gene Name NPC intracellular cholesterol transporter 1; NCBI Gene Aliases NPC, POGZ, SLC65A1; Target NPC1; Vector Name pLenti-C-mGFP; Molecular Weight 3834 bp; Selectable Marker Chloramphenicol (34 ug/mL) Conjugate/Tag/Label mGFP; Species Human; Add to Compare List. OriGene Technologies. how to make a circle using htmlWebCNS hypomyelination is one of the pathological characteristics of Niemann–Pick Type C disease (NPC), a rare childhood-onset neurodegenerative disorder due to mutations of NPC1 (NPC intracellular cholesterol transporter 1) or NPC2 . Npc1-deficient mice display hypomyelination and delayed myelination caused by hampered OL maturation [202,203]. how to make a chocolate birds nestWebNPC intracellular cholesterol transporter 1 (human) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure how to make a building planWebCreative Biolabs offers high-quality Rabbit Anti-NPC1 Monoclonal Antibody (PZR5209), BSA and Azide Free to boost neuroscience research. how to make a cat tailWeb4 apr. 2024 · NPC1 provided by HGNC Official Full Name NPC intracellular cholesterol transporter 1 provided by HGNC Primary source HGNC:HGNC:7897 … how to make a cake ball